Police said a 20-year-old man had been driving a blue Kawasaki motorcycle northbound, weaving in between two right lanes when he crashed into the back of a black Honda Civic and a gray Jeep Cherokee.
The motorcyclist was thrown from his bike and into a white Toyota Corolla.
He was pronounced dead at the hospital. His identity has not yet been released.
Two people in the Honda were also taken to a local hospital for back pain. At first, officials had said five vehicles were involved, but they later stated four vehicles were involved in the crash.
Several northbound lanes of the highway were closed Tuesday morning, but later reopened.
This crash is under investigation.