The crash took place on the B4393, near Llandrinio Bridge, at around 7.20am.
Police said the crash had involved a black Kawasaki motorcycle and a white Vauxhall van.
A spokesman for Dyfed-Powys Police said: “We received a report of a road traffic collision on the B4393 near Llandrinio bridge at around 7.20am on Monday, September 16.
The collision involved a white Vauxhall van and a black Kawasaki motorcycle. Sadly, the rider died at the scene.
“Their next of kin have been informed and are being supported by specialist officers.
Anyone who may have been travelling along the B4393 near Llandrinio bridge at the time, is asked to contact police.
“Investigating officers would particularly like to speak to any motorists who were in the area at that time who have dash cam in their vehicles.
